![]() ![]() Mild cognitive impairment (MCI) is an early stage of cognitive decline, which is a crucial time for brain health protection. Cognitive decline accelerates even in patients with AF at a young age when compared to those without AF ( 3). The risk of dementia is 2-fold higher in patients with AF than that in the population without AF ( 2). Cognitive dysfunction and dementia are one of the most concerning complications in patients with AF. Compared to the criterion MMSE ≤ 27 and MMSE norms for the elderly Chinese community, the stratified T-MoCA threshold improves correct classification by 23.7% ( p = 0.033) and 30.3% ( p = 0.020), respectively.Ĭonclusion: T-MoCA is a feasible and effective instrument for MCI screening in patients with AF.Ītrial fibrillation (AF) is one of the most common arrhythmias in adults, which remains to be a major public health challenge over the past decades ( 1). The optimal threshold was achieved at 16/17 with a sensitivity of 85.7% and a specificity of 69.7% in overall patients, 15/16 with a sensitivity of 88.2% and a specificity of 64.5% in the low educational level patients, and 16/17 with a sensitivity of 77.8% and a specificity of 87.9% in the high educational level patients. The areas under the ROC curve of T-MoCA were 0.80 (0.71–0.89), 0.83 (0.71–0.95), and 0.85 (0.64–0.92) for all patients, patients with high educational level, and patients with low education level, respectively. Thirty-five MCI patients were identified as MCI using the criteria of CDR = 0.5. Results: One hundred and one patients completed both telephone and in-person interview. The net reclassification index was calculated for comparison between the performance of T-MoCA and MMSE. ![]() Using CDR = 0.5 as a reference standard, the ability of T-MoCA and MMSE to discriminate cognitive dysfunction, stratified by education level, was tested by receiver–operating curve (ROC) analysis. Methods: Cognitive function was first evaluated using telephone Montreal cognitive assessment (T-MoCA), and then patients were invited for an in-person interview for cognitive assessment using both Clinical Dementia Rating (CDR) and mini-mental status evaluation (MMSE). However, feasible and simple instruments that facilitate the regular assessment of cognitive status in patients with AF remain underdeveloped. 4Department of Neurology, Beijing Anzhen Hospital, Capital Medical University, Beijing, Chinaīackground: Atrial fibrillation (AF) is associated with a high risk of mild cognitive impairment (MCI) and dementia.3School of Clinical Medicine, Peking Union Medical College and Chinese Academy of Medical Science, Beijing, China.2Beijing Advanced Innovation Center for Big Data-Based Precision Medicine for Cardiovascular Diseases, Beijing, China.1Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases, Beijing, China.Yiwei Lai 1,2 † Manlin Zhao 1,2 † Chao Jiang 1,2 * Xin Du 1,2 Zhiyan Wang 1,2 Jingrui Zhang 1,2 Yu Bai 3 Baolei Xu 4 Weiwei Zhang 4 Ribo Tang 1,2 Caihua Sang 1,2 Deyong Long 1,2 Jianzeng Dong 1,2 Changsheng Ma 1,2 * ![]()
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